Even small bouts of exercise protective against heart disease, cancer Cancer Exercise Heart HeartDisease BJSM_BMJ
Review: Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose–response meta-analysis of large prospective studies. Image Credit: Africa Studio / Shutterstock
This highlights the significance of prevalence estimates for PA levels and the approximation of the dose-response relationship between PA and CVD and cancer outcomes. Modeling studies have confirmed how crucial it is to determine the shape of the dose–response association, which, in turn, is needed to inform public health policies directed toward increasing PA at the population level.
The researchers screened Scopus, PubMed, and Web of Science databases to find prospective cohort studies that reported PA levels of adults with no pre-existing conditions in a minimum of three ordinal exposure levels to report risk estimates for all examined outcomes.i) cumulative mortality separately for all causes, CVDs and cancer;iii) Cumulative incidence of all fatal and non-fatal site-specific cancers, e.g., rectal cancer, selected based on prespecified criteria.
Results All the studies that met the inclusion criteria examined leisure-time PA, alone or in combination with specific types of activity. According to the authors, they so extensively harmonized PA exposure data that it fetched a more extensive evidence base for 17 of 22 health outcomes. Moreover, it is the first meta-analysis to estimate dose–response associations for nine site-specific cancers.
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