Nature research paper: Enantioselective Transition-Metal Catalysis via an Anion-Binding Approach
Asymmetric transition-metal catalysis represents a powerful strategy for accessing enantiomerically enriched molecules. The classical strategy for inducing enantioselectivity with transition-metal catalysts relies on direct complexation of chiral ligands to produce a sterically constrained reactive metal site that allows formation of the major product enantiomer while effectively inhibiting the pathway to the minor enantiomer through steric repulsion.
Here, we report a new approach for inducing enantioselectivity in transition-metal-catalyzed reactions that relies on neutral hydrogen-bond donors that bind anions of cationic transition-metal complexes to achieve enantiocontrol and rate enhancement through ion pairing in concert with other noncovalent interactions.
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