Dominant strain of norovirus uses 'unexpected mechanism' to enter and infect our cells: study

A new study of norovirus, a common virus that causes diarrhea and vomiting, is highlighting the 'unexpected mechanism' it uses to invade our cells.

A new study of a common virus that often causes the 'stomach flu' has made steps towards understanding how it invades our cells – and how to fight it.human norovirus uses an “unexpected mechanism”

Gastroenteritis is a relatively common condition in which a bacterial or viral infection causes diarrhea and vomiting. In children, the cause is usually rotavirus, but norovirus is behind most adult cases of gastroenteritis. In this new study, published in the peer-reviewed journal Nature Communications on Tuesday, researchers were aiming to dig into how noroviruses trigger these gastrointestinal affects.

When researchers introduced the virus to the intestinal cells, they observed that the virus was able to damage the membranes that protect the outer edge of a cell. “To our knowledge, this is a previously uncharacterized complex entry process into human enteroids that combines several independent pathways,” Estes, a professor and Cullen Foundation Endowed Chair of molecular virology and microbiology at Baylor College, as well as the corresponding author of the research, said in the release. “There may be more molecules involved in this entry pathway than what have been reported for other viruses.

The shell domain was also lending a hand, showing that the act of infecting another cell meant a restructuring of the virus too.

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