Doctors say gene therapy treatment, called CAR-T cell therapy, can attack cancer immediately, then stay inside the body for years and evolve there to keep the disease at bay.
- In 2010, doctors treated Doug Olson’s leukemia with an experimental gene therapy that transformed some of his blood cells into cancer killers. More than a decade later, there’s no sign of cancer in his body.
His doctors describe the two cases in a study published Wednesday in the journal Nature. They say the two examples show the treatment,, can attack cancer immediately, then stay inside the body for years and evolve there to keep the disease at bay. Such so-called “living drugs” are now used by thousands around the world to treat certain blood cancers.
He eventually underwent chemotherapy and, at one point, his physician, Dr. David Porter, suggested he may need a bone marrow transplant. Porter also raised the idea of joining a CAR-T therapy study. Olson, CEO of a New Hampshire lab products company, said he was excited by the science and eager to avoid the transplant.
Study author J. Joseph Melenhorst said they were able to isolate and analyze the cells using new technologies, which gave them “very good insight” into how they persisted in the patients’ bodies. The Nature study was paid for partly by the Novartis Institute for Biomedical Research and partly by National Institutes of Health grants.. Last year, a CAR-T cell therapy was approved for multiple myeloma, the most common malignancy of the bone marrow in adults. According to the Leukemia & Lymphoma Society, leukemia, lymphoma and myeloma were expected to make up just under 10% of the 1.9 million new cancer cases in the U.S. last year.
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