Predicting risk of bloodclots in brain tumors northwesternu
Venous thromboembolism is a life-threating condition that is common in patients with adult-type diffuse gliomas, yet thromboprophylaxis is controversial because of possible intracerebral hemorrhage. Effective VTE prediction models exist for other cancers, but not glioma. Our objective was to develop a VTE prediction tool to improve glioma patient care, incorporating clinical, blood-based, histologic, and molecular markers.
Tumor expression of tissue factor and podoplanin each positively correlated with VTE, although only circulating TF and D-dimers, not circulating PDPN, correlated with VTE risk. Gliomas with mutations in isocitrate dehydrogenase 1 or IDH2 caused fewer VTEs; multivariable analysis suggested that this is due to IDHsuppression of TF, not PDPN.
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