Katie Jennings is a senior writer at Forbes covering healthcare, technology and AI and a co-author of the InnovationRX newsletter. She joined Forbes in 2020 and is based in Jersey City.
The U.N. has proposed a target of ending AIDS by 2030. But it’s a pipe dream unless scientists are able to crack the code of one of the world’s sneakiest viruses and develop an effective vaccine.“Until there’s a cure or a vaccine, we will need to sustain the AIDS response beyond 2030,” UN AIDS Executive Director Winnie Byanyima said last month.
Around 39.9 million people worldwide are living with HIV and there are an estimated 1.3 million new infections each year, with cases rising in the Middle East and North Africa, Eastern Europe, central Asia and Latin America, according to theacknowledges “the world is off track.
There are several big challenges with HIV that boil down to the same principle: it’s a very sneaky escape artist that is constantly changing and using decoys to evade capture by the immune system. The usual approach for many vaccines is to introduce inactivated virus or pieces of virus into the body so that the immune system can prepare a response in advance of infection.
He likens the current efforts by scientists working on multiple types of vaccine responses to top-secret World War II codebreakers in England’s Bletchley Park. “You're trying to solve something that's unknown, and you're getting together the best minds to figure out how to decode the enigma machines,” said Yang, though he is not confident that an HIV vaccine is currently possible without a major breakthrough.
AIDS Gilead Prep Lenacapavir Vaccine UNAIDS AIDS24
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