Dr. Allis's work opened new ways to treat some blood cancers and stirred wider medical research into gene-targeting drugs for other diseases.
Dr. Allis’s discoveries reshaped knowledge of the genetic “on-off” and “volume” switches known as, in which information encoded in a gene is turned into a function such as making proteins and ribonucleic acid, or RNA, molecules that help regulate body functions. Any flaws in the process, such as not triggering a gene or stimulating it too much, can open the way for biological imbalances and possible disease.
Dr. Allis peered into proteins, known as histones, that are nature’s shrink wrap: squeezing the long DNA threads into cellular packets. Thedescribed it as the equivalent of “packing 24 miles of extremely fine thread into a tennis ball.”
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