Coronavirus disease (COVID-19) hijacks parts of infected cells' vital RNA machinery, thereby blocking important functions in the cells. These damaging changes in the RNA can likely be reversed, potentially leading to new drugs against COVID-19, University of Gothenburg researchers show. Genetic m
University of Gothenburg researchers have discovered that COVID-19 hijacks the vital RNA machinery in infected cells, causing damaging changes that could potentially be reversed with new drugs. The study found that SARS-CoV-2 infection disrupts RNA modifications, including m6A, a crucial regulator of gene expression. The extent and drastic scale of m6A RNA modification loss surprised the researchers, and they also observed that different coronavirus variants have varying effects on m6A levels.
The group behind the findings: Roshan Vaid, Tanmoy Mondal, Kristina Nyström and Ketan Thombare. Credit: Elin LindströmA , is highly important for RNA’s basic functions, including transportation of data to the protein-making parts of the cell, and transcription and translation intoA RNA modification loss in SARS-CoV-2 infection.
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