COVID-19 Antibody Tests Can Be Wrong Half The Time, CDC Says

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COVID-19 Antibody Tests Can Be Wrong Half The Time, CDC Says
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These blood tests have significant margins of error and should not be used to make public health recommendations, the CDC said.

are capable of being incorrect roughly half of the time and should not be used to determine whether physical distancing or use of personal protective equipment is no longer necessary, the Centers for Disease Control and Prevention said.

If only a small percentage of those being tested are infected, the tests’ margin of error will be higher, whereas if the rate of infection is higher among those being tested, the positive predictive value increases, the CDC explained.A staff member works on coronavirus serology tests at the Biogroup-LCD laboratory's technical platform in Levallois-Perret, near Paris, France.

“In most of the country, including areas that have been heavily impacted, the prevalence of SARS-CoV-2 antibody is expected to be low, ranging from less than 5% to 25%, so that testing at this point might result in relatively more false positive results and fewer false-negative results,” the CDC said. It’s possible that in areas where only a small percentage of those being tested are infected, “less than half of those testing positive will truly have antibodies.

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