Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group has found a new way to do so.
Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group led by Nikolaus Rajewsky has found a new way to do so. They report their work inThey look like storm clouds that could fit on the head of a pin: Organoids are three-dimensional cell cultures that play a key role in medical and clinical research.
The researchers used light to activate a morphogen called Sonic Hedgehog. Their subsequent spatially resolved single-cell analyses showed that the cells responded by arranging themselves into stereotypically patterned organoids. The researchers created the light in two ways: using either a laser microscope or a digital micromirror device, which Rajewsky's group developed in collaboration with Dr. Andrew Woehler. At the time, Dr.
A team has developed an ingenious device, using layers of hydrogels in a cube-like structure, that allows researchers to construct complex 3D organoids without using elaborate techniques. The group ...
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