A Review published in Cancer Cell International assesses the association between circulating exosomal microRNAs and their prognostic role in gastrointestinal cancer patients.
The research question has been developed using PFO; “P” as Population, “F” as Prognostic Factors , and “O” as Outcome [i) Observational studies assessed the association between circulating exomiRs and GI cancers.iii) Studies with human GI cancers, including upper and lower GI and hepatopancreatic biliary.
iv) Studies assessing the association between the circulating exomiRs expression and the prognostic values consisting of overall survival , disease/relapse/progression-free survival , and/or clinicopathological characteristics of GI cancers. v) Hazard ratios and 95% confidence intervals provided in the article, or availability of data to calculate HRs with 95% CIs.i) Reviews, meta-analysis, commentaries, case reports, case series studies.iv) Studies with insufficient and useless data or with unavailable full text.The literature was searched in electronic databases, comprising of Web of Science, PubMed/MEDLINE, Scopus, and Embase until 31st July 2017 and updated on 7th September 2022.
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