A recent study by researchers at Columbia University Vagelos College of Physicians and Surgeons suggests that chemicals present in the vagina, possibly from personal care products, may play a role in causing spontaneous preterm birth. A study of 232 pregnant women revealed that a small number of
Preterm birth, also known as premature birth, is the delivery of a baby before 37 weeks of pregnancy. This can lead to a range of health complications for both the baby and the mother, including low birth weight, breathing difficulties, and developmental delays.Vagelos College of Physicians and Surgeons suggests that chemicals present in the vagina, possibly from personal care products, may play a role in causing spontaneous preterm birth.
“Our findings suggest that we need to look more closely at whether common environmental exposures are in fact causing preterm births and, if so, where these exposures are coming from,” says study co-leader Tal Korem, Ph.D., assistant professor in the Program for Mathematical Genomics and the Departments of Systems Biology and Obstetrics and Gynecology at Columbia. “The good news is that if these chemicals are to blame, it may be possible to limit these potentially harmful exposures.
The research team, co-led by Korem and Maayan Levy, Ph.D., of the University of Pennsylvania, decided to take a more expansive view of the vaginal microenvironment by looking at its metabolome. The metabolome is the complete set of small molecules found in a particular biological niche, including metabolites produced by local cells and microorganisms and molecules that come from external sources. “The metabolome can be seen as a functional readout of the ecosystem as a whole,” Korem says.
The study found multiple metabolites that were significantly higher in women who had delivered early than in those who delivered at full term.
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