Cardiovascular diseases disrupt the bone-marrow niche

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Cardiovascular diseases disrupt the bone-marrow niche
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Imbalances in blood-cell production could affect disease outcome.

). The development and progression of cardio-vascular disease could be influenced by a perturbation in the balance of haematopoiesis, the process by which blood cells are generated from haematopoietic stem and progenitor cells .

Indeed, inflammatory blood cells that are derived from haematopoietic progenitor cells in the bone marrow have been implicated in cardiovascular disorders such as athero-sclerosis, a condition in which cholesterol builds up in the arteries; myo-cardial infarction ; and ischaemia, a form of heart failure that results from a lack of oxygen supply . This relationship between the cardiac and haemato-poietic systems was thought to be unidirectional.

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