A novel ultrasound technique utilizing microbubbles temporarily opens the blood-brain barrier to treat glioblastoma in humans. One of the biggest challenges in treating glioblastoma, a fatal brain cancer, is that the most effective chemotherapy drugs cannot penetrate the blood-brain barrier to reac
The first human trial of a novel ultrasound device demonstrated its potential to temporarily open the blood-brain barrier and deliver chemotherapy directly to the brain. This innovative procedure led to a significant increase of four to six times in drug concentrations in the brain, and patients were awake during the four-minute procedure which was repeated every few weeks for several months.
The four-minute procedure to open the blood-brain barrier is performed with the patient awake, and patients go home after a few hours. The results show the treatment is safe and well tolerated, with some patients getting up to six cycles of treatment. This video demonstrates the dynamic opening of the BBB opening intra-operatively. Following brain sonication and administration of intravenous microbubbles, scientists injected fluorescein intravenously, as this dye does not normally penetrate into the brain. They first observed fluorescein in the arteries, then the whole brain was fluorescent, as this dye was in the capillaries, followed by the brain veins.
“There is a critical time window after sonification when the brain is permeable to drugs circulating in the bloodstream,” Sonabend said. In the phase 1 clinical trial reported in this paper, patients underwent surgery for resection of their tumors and implantation of the ultrasound device. They started treatment within a few weeks after the implantation.
France Dernières Nouvelles, France Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Texas DL Moro Ojomo continues his journey with the Philadelphia EaglesTexas defensive lineman Moro Ojomo had his long-awaited breakthrough as a fifth-year senior. Now, he's beginning a new journey with the Philadelphia Eagles.
Lire la suite »
Nanoscale Breakthrough – A Single-Molecule ValveA revolutionary paradigm shift that will transform chemical and biochemical synthesis is on the horizon. The scientific community envisions utilizing minute molecules as foundational elements to construct objects, similar to how we assemble things with mechanical components. However, the challenge
Lire la suite »
Bill Gates: Natrium power plant, ‘next nuclear breakthrough’ might be ready by 2030Meanwhile, a start-up financed by Bill Gates has also revealed plans to develop a 1.2GW electrolyzer gigafactory in Massachusetts that would produce the 'world's most powerful electrolyzers.'
Lire la suite »
Oakland teachers to strike for 3rd day as breakthrough comes in negotiations with districtAs teachers head back to the picket lines Monday, OUSD is now willing to negotiate the full package the union has been demanding, including 'common good' proposals. Here's what that means.
Lire la suite »
Defeating Blood Cancer: New Strategies for Effective TreatmentMultiple myeloma is a rare type of blood cancer that occurs due to the excessive proliferation of abnormal plasma cells. Plasma cells, a specific type of white blood cell, play a crucial role in the immune system by generating crucial antibodies in both the bone marrow and lymph nodes. Although t
Lire la suite »
Designing and Using Antibody-Drug Conjugates to Treat Solid Tumors📍 How much do you know about antibody-drug conjugates for solid tumor management? MedEd CME
Lire la suite »