Calgary researcher Fred Van Goor was named a co-recipient of the prize in life sciences with Sabine Hadida and Paul Negulescu
A Canadian biomedical researcher who helped to revolutionize the treatment of cystic fibrosis is among the latest winners of the Breakthrough Prize, the world’s largest award for advances in physics, mathematics and biomedicine.
The son of a physician, Dr. Van Goor said his scientific journey began when he was a student at the University of Alberta, where he intended to study medicine and instead became captivated by the world of research. It was a Vertex that he took on the challenge of fixing CFTR, a protein that projects through the membrane of cells and, in healthy individuals, helps the body produce mucus, saliva and sweat. Because of genetic variations, patients with cystic fibrosis produced malformed CFTR, leading to the build-up of mucus in various organs, including the lungs.
By 2012, Dr. Van Goor and his colleagues had their first successful drug, known by the trade name Kalydeco. It proved effective in a small subset of cystic fibrosis patients but paved the way to further drug combinations that address a wider variety of genetic mutations found in many more individuals with the disease.
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