None of the current studies on microdosing reach standards that enable scientists to draw firm conclusions. But results from recent studies using a single high-dose psychedelic have illuminated the mental-health potential
But in addition to the issue of users taking non-standardized doses, participants were all microdosing before the studies began, so they may have been biased. “We have to be cautious about not overinterpreting the encouraging retrospective reports that have appeared in the literature,” Yale’s Krystal says. “The concern about first-person experiences is that there is often tremendous potential for placebo effects to color the interpretation.
An earthy platter showcases the many shapes of the Hillbilly mushroom. The psychedelic effects of these fungi can kick in as quickly as 15 to 30 minutes after a microdose, peak in 60 to 90 minutes, and mostly disappear after about six hours.This was a clever way to study a large number of microdosers in the current regulatory environment, says Garcia-Romeu, who helped to evaluate the research for the journal.
Others microdose to self-treat mental-health conditions. Karen Gilbert, a 69-year-old retired nurse in Lopez Island, Washington, is hoping microdosing psilocybin, which she started in November, might help with the depression she has suffered for more than two decades. One of Zelfand’s patients, Gilbert says she noticed a difference almost immediately.
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