The CRISPR gene editing technique has revolutionised biology, but now an even more powerful system called bridge editing could let us completely reshape genomes
A powerful form of DNA-editing machinery discovered in bacteria might allow us to make much bigger changes to genomes than is currently possible with CRISPR-based techniques. However, it is not yet clear whether it will work in human cells.at the Arc Institute in Palo Alto calls the new genome editor the “bridge editing” system because it physically links, or bridges, two pieces of DNA.
There are two parts to the standard CRISPR Cas9 protein. One part links up with a guide RNA and seeks out any DNA that matches a certain section of the guide RNA. Because it’s easy to make custom guide RNAs, this means that CRISPR Cas9 can be “programmed” to seek out any part of the genome.The second part of CRISPR Cas9 is a cutter that severs DNA once the Cas9 has bound to its target site.
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