Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration

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Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration
France Dernières Nouvelles,France Actualités
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New biomarker test can detect Alzheimer's neurodegeneration in blood

Plasma BD-tau shows high potential as a neurodegeneration biomarker of the Alzheimer's type. We anticipate that combining plasma BD-tau with p-tau and possibly Aβ42/Aβ40 will increase accuracy of a blood biomarker-based diagnosis of Alzheimer’s disease by increasing its agreement with results obtained at autopsy or by using CSF or neuroimaging biomarkers.

In the present study, we report a novel blood biomarker specific for BD-tau. Validation showed strong correlations between paired blood and CSF measures, and we verified a high performance to specifically identify Alzheimer’s disease-type neurodegeneration.

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