Biochemists describe structure and function of newly discovered CRISPR immune system USUAggies nature
"With this new system, known as Cas12a2, we're seeing a structure and function unlike anything that's been observed in CRISPR systems to date," says Jackson, assistant professor in Utah State's Department of Chemistry and Biochemistry.
USU biochemists describe the structure and function of Cas12a2. Credit: Taylor Emerson, Utah State University "The Cas12a2 protein undergoes major conformational changes upon binding to RNA that opens an indiscriminate active site for DNA destruction," Jackson says."Cas12a2 destroys the DNA and RNA inor"cryo-EM," the USU team demonstrated this unique aspect of CRISPR-Cas12a2, including its RNA-triggered degradation of single-stranded RNA, single-stranded DNA and double-stranded DNA, resulting in a naturally occurring defensive strategy called abortive infection.
Jackson says the difference between a healthy cell and a malignant cell or infected cell, is genetic.at the genetic level, the potential therapeutic applications are significant," he says.
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