In recent years, the beverage has emerged as a strong candidate for implementation into psychiatric care, particularly for patients with treatment-resistant depression. PsychTwitter
a team of researchers from Brazil's Federal University of Rio Grande do Norte describe an experimental ayahuasca session. They found that specific emotional and physiologic parameters were critical moderators of improvement in major depression biomarkers, mainly serum brain-derived neurotrophic factor and serum cortisol , 2 days after ayahuasca intake.
All volunteers underwent a full clinical mental health evaluation and medical history. Blood and saliva samples were collected at baseline, approximately 4 hours before the dosing session, and 2 days after the dosing session. During the dosing session, saliva samples were collected at 1 h 40 min, 2 h 40 min, and 4 h after ayahuasca intake.
As for biomarkers, Galvão-Coelho said that there is a long history of research on cortisol with respect to patients with depressive symptoms, given the link between chronic stress and depressive disorders."In our patients with treatment-resistant depression, we found that before being dosed with ayahuasca, they presented hypocortisolemia," she said. She noted that low levels of cortisol are as harmful to one's health as high levels.
Considering all the previous findings, the team wondered whether acute parameters recorded during an ayahuasca dosing session could in some way modulate the responses of certain key MDD molecular biomarkers. They then conducted their study that was published last December.
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