Bacterial outer membrane vesicles: utility as vaccines and novel engineering approaches FrontiersIn FrontMicrobiol Merck bacteria microbiology vaccine vesicles
By Dr. Sanchari Sinha Dutta, Ph.D.Jan 3 2023Reviewed by Danielle Ellis, B.Sc. In an article published in Frontiers in Microbiology, scientists have described the utility of gram-negative bacteria-derived outer membrane vesicles as vaccines and methods to expand their applications.
Bacterial proteins and glycans make OMVs a potent immunogenic component that can be used as adjuvants to induce host immune response. Because of this property, OMVs are considered potential candidates for vaccine development. OMVs extracted by EDTA closely relate to the native bacterial membrane and induce comparable immune responses. In contrast, sonication and vortexing increase the amount of non-membrane components in the final product, resulting in increased antigenicity and reduced safety.
Heterologous OMVs Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Non-pathogenic bacterial strains can express heterologous proteins to reduce toxicity and improve the immunogenicity of OMVs. OMV-induced immune response The pathogen-associated molecular patterns present on the OMV outer membrane activate the pattern recognition receptors on the host cells, leading to the activation of innate immune signaling and the release of proinflammatory cytokines. The engulfment of OMVs by innate immune cells induces adaptive immune responses.
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