‘Astonishing’ molecular syringe ferries proteins into human cells

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‘Astonishing’ molecular syringe ferries proteins into human cells
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Researchers have hijacked a molecular ‘syringe’ that some viruses and bacteria use to infect their hosts, and put it to work delivering potentially therapeutic proteins into human cells

cells, because those cells can be reached using the current delivery methods, he says. “The reason we don’t see brain or kidney diseases getting tackled is because we don’t have good delivery systems.”

Last year, Jiang and his colleagues reported that they could manipulate this syringe-like system in the bioluminescent bacterium. Normally, the bacterium lives inside nematodes and uses its syringe to transport a toxin into the cells of insects infected by the nematode. The toxin kills the insect, and the nematode eats the remains.

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