CARTtherapy induced remission in 5 patients with systemic lupus erythematosus. In our latest News and Views, Jane Salmon WeillCornell puts the data in context and discusses next steps for the field. SLE lupus CARTcells
Systemic lupus erythematosus is a prototypic autoimmune disease whose immunological hallmark is the production of antinuclear antibodies.
These bind DNA, RNA and associated proteins, leading to deposition of immune complexes and induction of inflammation, cytokine release and organ damage — with lupus nephritis being among the most serious manifestations.
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