An engineered protein engages the efferocytosis pathway to induce beta-amyloid engulfment, resulting in behavioral rescue in Alzheimers models without the increased inflammation or vascular pathology seen with conventional antibody therapy. wonsukchung
, Coomassie brilliant blue staining of SDS-PAGE gel showing purified Aducanumab . Representative data from, Representative kinetic graphs showing oAβ-pHrodo uptake assays using two different cell lines, THP-1 and HMC3 , which were treated with LV-Aducanumab or LV-αAβ-Gas6, respectively, along with the control virus. One-way ANOVA followed by Tukey’s multiple comparison test. Mean ± s.e.m.
Extended Data Fig. 6 Activation of glial cells in cannula-implanted brains and measurement of plaque burden in CAA-induced brains., Representative confocal z-stack images of MERTK , AXL , GFAP , and IBA1 in the contralateral and ipsilateral cortex of PBS , Aducanumab , and αAβ-Gas6 infused 5xFAD mice. White dashed lines indicate the site of cannula implantation.
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