Ideal for those feeling the cold at the moment
For those feeling the cold at the moment - and that's basically everyone in the UK - keeping yourself warm and cosy is a battle. Temperatures have dipped, with Nottinghamshire recording its coldest night of the year at -7.8C and the Met Office predicting that the mercury will continue to show minus figures at various points for the next few days and nights.
Posting on an Aldi Shoppers Facebook page, one fan of the store wrote: "Absolute bargain real lamb skin £19.99". Fellow shoppers soon swooped on the post to give their opinions with one describing them as 'lush', another, who had previously purchased a pair added: "The quality is amazing and my feet are so warm too", and someone else agreeing: "They are the best".
Another called them "Beautifully Comfy Lambskin Boots". The reviewer added: "Perfect. Keep feet fresh and warm without causing feet to sweat. Highly recommended - Great value for money."
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Nanopore long-read-only metagenomics enables complete and high-quality genome reconstruction from mock and complex metagenomes - MicrobiomeBackground The accurate and comprehensive analyses of genome-resolved metagenomics largely depend on the reconstruction of reference-quality (complete and high-quality) genomes from diverse microbiomes. Closing gaps in draft genomes have been approaching with the inclusion of Nanopore long reads; however, genome quality improvement requires extensive and time-consuming high-accuracy short-read polishing. Results Here, we introduce NanoPhase, an open-source tool to reconstruct reference-quality genomes from complex metagenomes using only Nanopore long reads. Using Kit 9 and Q20+ chemistries, we first evaluated the feasibility of NanoPhase using a ZymoBIOMICS gut microbiome standard (including 21 strains), then sequenced the complex activated sludge microbiome and reconstructed 275 MAGs with median completeness of ~ 90%. As a result, NanoPhase improved the MAG contiguity (median MAG N50: 735 Kb, 44-86X compared to conventional short-read-based methods) while maintaining high accuracy, allowing for a full and accurate investigation of target microbiomes. Additionally, leveraging these high-contiguity reference-quality genomes, we identified 165 prophages within 111 MAGs, with 5 as active prophages, indicating the prophage was a neglected source of genetic diversity within microbial populations and influencer in shaping microbial composition in the activated sludge microbiome. Conclusions Our results demonstrated that NanoPhase enables reference-quality genome reconstruction from complex metagenomes directly using only Nanopore long reads. Furthermore, besides the 16S rRNA genes and biosynthetic gene clusters, the generated high-accuracy and high-contiguity MAGs improved the host identification of critical mobile genetic elements, e.g., prophage, serving as a genomic blueprint to investigate the microbial potential and ecology in the activated sludge ecosystem. Video Abstract
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Aldi selling UK's cheapest fresh whole turkeys in price comparison - full listThe budget supermarket has beat major retailers including Sainsbury's, Tesco and Asda.
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I opened Quality Street, Heroes, Celebrations & Roses to see what’s in each oneI opened the Quality Street, Heroes, Celebrations & Roses to see what’s in each one - and there were a few surprises
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Aldi hints at plans to roll out click and collect as part of 2023 plansTHE Aldi boss wants “Brits to celebrate Christmas without breaking the bank.” It comes as he gears up for the discounter to poach more shoppers from its rivals this month than ever before. In…
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Cheapest supermarket at Christmas named and it's not Aldi or LidlThe UK's leading supermarkets were put to the test on the price of a full Christmas dinner with all the trimmings
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Vampire Survivors readies quality-of-life changes and fixes for DLC launchDeveloper Poncle has detailed Patch 1.2, a new update coming to Vampire Survivors alongside the Legacy of the Moonspell DLC that's filled with quality-of-life changes and bug fixes.
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