After 3 Children Die, a Race to Investigate a Baffling Virus Syndrome

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After 3 Children Die, a Race to Investigate a Baffling Virus Syndrome
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NEW YORK -- Blood will be collected from dozens of children in New York to determine whether they share any genetic variations that might make them susceptible to a mysterious syndrome linked to the coronavirus.Tissue samples from at least one of the three patients to have died from it -- ages 5, 7 and

NEW YORK — Blood will be collected from dozens of children in New York to determine whether they share any genetic variations that might make them susceptible to a mysterious syndrome linked to the coronavirus.

The ailment has now been reported in at least 161 children in New York, making the state’s caseload one of the largest publicly reported anywhere. Hundreds of other children across the United States and in Europe have also been sickened with the illness, now called multisystem inflammatory syndrome. He added, “It does keep you up at night. It’s the worry that, is there something we’re going to figure out in six months from now, and we’re going to say, ‘How did we not think about that possible therapy? How did we not figure out that this would have helped?’”

Another doctor spoke of troubling heart ailments in children afflicted with the illness. A third talked about treating a 14-year-old in the Bronx who was admitted in good condition but then rapidly deteriorated. Almost immediately, doctors noticed that in some patients the symptoms bore a striking overlap to a rare childhood illness called Kawasaki disease, which involves inflammation of the blood vessels and whose symptoms can range from redness of the eyes to damaged coronary arteries that can lead to heart attacks and aneurysms.

“Those early days, it was just trying to get as much information from the providers to understand what they were seeing, what was unusual,” Lee said. A few have required even more drastic intervention, including extracorporeal membrane oxygenation, in which blood is removed from the body and oxygenated by means of a membrane before being pumped back into the patient, doctors said.

The time lag and the signs of inflammation have led many doctors to suspect the new syndrome is caused by “an aggressive, abnormal immune reaction to COVID exposure,” said Dr. George Ofori-Amanfo, chief of pediatric critical care for the Mount Sinai Health System.

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