A therapeutic target for highbloodpressure control yale jclinicalinvest
and contributes about $131 billion annually to the cost of healthcare services according to the Centers for Disease Control and Prevention. Almost half of the individuals with hypertension or conditions linked to blood pressure are unable to reach a target blood pressure below 120/80 mmHg.
A broader understanding of disease pathways driven byfor hypertension and high throughput assays, they established the role of PRDM6 in the regulation of blood pressure. By generating different transgenic mouse models, Yale scientists were able to show that the PRDM6 gene plays an essential role in restraining the number of renin-producing cells during embryonic development. Renin is an enzyme produced in the kidney and if elevated can cause hypertension.
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