Degenerative retinal disease is a problem for millions of people worldwide, as light-sensitive cells called photoreceptors at the back of the eye die without being replaced.
worldwide, as light-sensitive cells called photoreceptors at the back of the eye die without being replaced. Thanks to new research, a solution to the problem might not be far off.Müller glial cells
Part of the reason the Müller glial cells were chosen for investigation is their ability to be reprogrammed in some animals. Unfortunately it's not a trick that these cells can do in humans. Key to the study were the genes Ikzf1 and Ikzf4, and the proteins they produced. These proteins are known as temporal identity factors, already known to play important roles in the development of cells into various types.
While glial cells help nourish, regulate, and organize other cells in the eye, the researchers say there's enough of a surplus to safely convert a number of the support cells into the photoreceptor-like cells – crucial for seeing light and identifying colors.
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