Virus-like particles offer a new way to investigate genetic variation in SARSCoV2. Learn more in a new SciencePerspective:
introduced a key innovation. They first identified the SARS-CoV-2 packaging signal, a genetic marker used to identify full-length genomes for packaging into the virion . This packaging signal was incorporated into the 3’ untranslated region of a luciferase reporter plasmid, causing the resulting transcripts to be packaged within VLPs. Syedshow that VLPs deliver these luciferase reporters to target cells, allowing the resulting signal to be used as a proxy for SARS-CoV-2 infection.
In the broader context of studying SARS-CoV-2 genetic variation, VLPs represent a middle ground between two commonly used methodologies: infectious clones and pseudovirus vectors. SARS-CoV-2 infectious clones are the gold standard because they create recombinant virus, incorporating mutations anywhere in the genome . However, using SARS-CoV-2 infectious clones is technically challenging and creates live SARS-CoV-2 that requires BSL3 laboratories for study.
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