A mysterious condition makes marijuana users violently ill, and it reveals a hidden downside to the drug's growing popularity

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A mysterious condition makes marijuana users violently ill, and it reveals a hidden downside to the drug's growing popularity
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Interviews with researchers, doctors, and patients with cannabinoid hyperemesis syndrome reveal a severe and mysterious illness tied to heavy cannabis use.

Moon had been using various forms of marijuana daily for about three years. Then one day in 2016, several hours after smoking part of a joint, she ended up bowled over with nausea.

Within about a week in the ER, Moon developed three ulcers, a hernia, and an infection. She dropped 12 pounds from her already slender frame, missed Christmas with her family and New Year's with her friends.In Colorado, CHS was a leading driver of ER visits between 2012 and 2016.

Habboushe believes heat helps because of something to do with the way CHS interferes with the body's natural temperature and pain controls. For some reason, hot water signals to the body that everything is okay, and the pain and nausea from CHS subside for at least as long as the water remains scalding.

Frederick said her episodes of vomiting and nausea tend to happen when she's on her menstrual cycle and when she's traveling or dealing with added stress. She had her first episode after she got a small upper-arm birth-control implant, which releases the hormone progestin to prevent pregnancy. "It's not a normal, 'Oh, I'm sick to my stomach' feeling. You feel like your insides want to come out — like you're trying to push something out," Howard told Business Insider.If someone with CHS keeps using marijuana, severe complications may unfold. In one case, a 17-year-old in Indiana named Brian Smith died after struggling with CHS for more than six months.

After putting Smith on fluids and running a series of tests, they decided to keep him in the hospital overnight. The next two months were excruciating for Denney. Although her son had stopped vomiting — at least as far as she could tell — he continued to lose weight. He also occasionally complained about nausea. At first, she assumed it was related to his heartburn. But one day when she noticed his shoulder blades poking out from the thin cotton of his T-shirt, she began to suspect he was using cannabis again.

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