A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia

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A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia
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By combining CAR_Tcells with a selective IL-2 activation strategy, researchers find that they can expand and stimulate CAR T cells against leukemia in mice while preventing relapses. ScienceTM Cancer

We thank the members of the following facilities at the University of Pennsylvania: the Flow Cytometry Core for cell sorting, the Human Immunology Core for providing T cells from normal donors, the Translational and Correlative Studies Laboratory for performing Luminex Assays, the Laboratory Animal Resources, the Stem Cell and Xenograft Core for the tumor and CAR T cell injections and drawing blood from mice, and the Comparative Pathology Core for immunohistochemistry, image acquisition, and...

The research reported in this publication was supported by grants from NIH National Cancer Institute and institutional funds of the University of Pennsylvania. The Penn Vet Comparative Pathology Core is supported by the Abramson Cancer Center Support Grant . The scanner used for whole slide imaging was supported by an NIH Shared Instrumentation Grant . K.C.G.

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