“We wanted to set the record straight,” one of the doctors involved in the clinical trials said.
People with late liver failure can develop brain problems that affect thinking, Hohmann said. These patients also have very altered gut bacteria, and one hypothesis is that compounds created by these gut microbes can get into the bloodstream and affect the brain, she said.
These patients tend to have abnormal microbiomes, Hohmann said, in part because leukemia treatment makes them prone to infections and as a result, they receive a lot of antibiotics.But this patient developed the same life-threatening infection withshortly after FMT was finished. Indeed, the same type of E. coli from the same stool donor was found in the patient’s bloodstream, testing revealed. Despite aggressive treatment, Hohmann and her colleagues wrote, they weren’t able to save the patient.
Following the patient death, the FDA announced guidelines requiring that both donors and their stool be screened for multidrug-resistant organisms, including the one implicated in these two cases. But it’s important to remember that there may be other such organisms out there that aren’t being screened for, Hohmann said. “We can increase the ways we look for this, but we can’t 100 percent eliminate it,” she added.
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