COVID brain fog and chemo fog may not be so different.
of mice and people, posted January 10 at bioRxiv.org, that has not yet been reviewed by other scientists. By analyzing human tissue and mice infected with SARS-CoV-2, researchers showed that immune cells called microglia are overactive in the brain. When microglia shift into high gear, they can damage surrounding brain tissue.
Microglia were more active in the brains of mice infected with SARS-CoV-2 than in uninfected mice. A similar pattern emerged when the researchers studied postmortem brain tissue from nine people who died with COVID-19. It’s not clear how well these samples represent the majority of people who experienced mild COVID and are living with the aftereffects.
The new results come with caveats, says neurologist Svetlana Blitshteyn of the University at Buffalo Jacobs School of Medicine and Biomedical Sciences in New York, who also directs the Dysautonomia Clinic. “They’re small studies, and obviously they are not definitive,” she says, “but the preliminary evidence speaks for itself.” It’s becoming clearer now that the brain fog that comes after an infection may be “rooted in neuroinflammation.
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