A Biotech Startup Used DMT to Successfully Treat Depression

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A Biotech Startup Used DMT to Successfully Treat Depression
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The findings add further fuel to expand access to psychedelics as a form of treatment for depression and a host of other mental health disorders.

A London biotech startup announced Wednesday that it had found success in treating major depressive disorder with intravenous DMT in a clinical trial. Though follow-up trials will be necessary to further prove out the drug’s efficacy, the findings add further fuel to the push to expand access to pDMT, the acronym for N,N-Dimethyltryptamine, is best known as a psychedelic drug that elicits a very rapid, very intense, and relatively short duration of hallucinogenic effects .

“I’m delighted by our short term results,” George Tziras, the CEO of Small Pharma, said on a conference call announcing the findings Wednesday. “With these results, we feel confident with moving forward with our SPL026 program.” As part of the study’s first arm, Small Pharma’s researchers found that patients who received SPL026 followed by supportive therapy found a 10.8 point difference in reduction in depression symptoms on the MADRS scale one week after the initial dose, compared to those who received the placebo. After two weeks, the MADRS score difference was 7.4—a small shrink, but still high.

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