DealClincher: 42% off Ridley Helium SLX Disc Custom Paint Edition Frameset
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This Ridley Helium SLX Frameset is ideal for contouring those big hills you may be scared of on your current bike!Commerce content is independent of editorial, and Farrelly Atkinson earns commission from promoted products The Ridley Helium SLX Disc frameset comes in at an astonishing weight of only 780 grams allowing you to have a full build for well under 7kg!
Riden by Thomas De Gendt, AKA Breakaway King master of one-minute 500W blasts, repeatedly races this bike to success thanks to its stiffness. The ultra-thin seat stays provides comfort without sacrificing a single watt. Furthermore, the Helium allows for integrated cable routing which means you gain 15 watts without even having to pedal.Commerce content is independent of editorial, and Farrelly Atkinson earns commission from promoted products
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Only 12 people in Glasgow handed fixed penalty for littering last yearA Freedom of Information request has revealed that 42 fixed penalties were handed out across Scotland for littering last year, with 12 being issued in the Greater Glasgow area
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Kerry Katona reveals she's had a tummy tuck after botched surgeryKERRY Katona has revealed she has had a tummy tuck after previously breaking down over botched surgery. The 42-year-old is no stranger to cosmetic procedures, but has gone under the knife again to …
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Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study - Critical CareBackground In-hospital acute resuscitation in trauma has evolved toward early and balanced transfusion resuscitation with red blood cells (RBC) and plasma being transfused in equal ratios. Being able to deliver this ratio in prehospital environments is a challenge. A combined component, like leukocyte-depleted red cell and plasma (RCP), could facilitate early prehospital resuscitation with RBC and plasma, while at the same time improving logistics for the team. However, there is limited evidence on the clinical benefits of RCP. Objective To compare prehospital transfusion of combined RCP versus RBC alone or RBC and plasma separately (RBC + P) on mortality in trauma bleeding patients. Methods Data were collected prospectively on patients who received prehospital transfusion (RBC + thawed plasma/Lyoplas or RCP) for traumatic hemorrhage from six prehospital services in England (2018–2020). Retrospective data on patients who transfused RBC from 2015 to 2018 were included for comparison. The association between transfusion arms and 24-h and 30-day mortality, adjusting for age, injury mechanism, age, prehospital heart rate and blood pressure, was evaluated using generalized estimating equations. Results Out of 970 recruited patients, 909 fulfilled the study criteria (RBC + P = 391, RCP = 295, RBC = 223). RBC + P patients were older (mean age 42 vs 35 years for RCP and RBC), and 80% had a blunt injury (RCP = 52%, RBC = 56%). RCP and RBC + P were associated with lower odds of death at 24-h, compared to RBC alone (adjusted odds ratio [aOR] 0.69 [95%CI: 0.52; 0.92] and 0.60 [95%CI: 0.32; 1.13], respectively). The lower odds of death for RBC + P and RCP vs RBC were driven by penetrating injury (aOR 0.22 [95%CI: 0.10; 0.53] and 0.39 [95%CI: 0.20; 0.76], respectively). There was no association between RCP or RBC + P with 30-day survival vs RBC. Conclusion Prehospital plasma transfusion for penetrating injury was associated with lower odds of death at 24-h compared to RBC alone.
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Association of loneliness and social isolation with all-cause mortality among older Mexican adults in the Mexican health and aging study: a retrospective observational study - BMC GeriatricsBackground Plenty of evidence shows how social isolation and loneliness are associated with increased risk for numerous diseases and mortality. But findings about their interactive or combined effects on health outcomes and mortality remains inconclusive. Objective Analyze the longitudinal association of loneliness, social isolation and their interactions, with the all-cause mortality among older adults in Mexico. Methods A retrospective observational study was conducted. Mexican adults older than 50 years were included. Data from the Mexican Health and Aging Study (MHAS) in the 2015 and 2018 waves were used. The subjects were classified according to their level of loneliness and the presence of social isolation. Multivariate logistic regression analyzes were performed to determine the degree of association between loneliness and social isolation with all-cause mortality at a 3-year follow-up. Results From the total sample of 11,713 adults aged 50 years or over, 707 (6%) did not survive, 42% presented loneliness, and 53% were classified as socially isolated. After multivariate adjustment only social isolation (OR = 1.30, 95%CI:1.03–1.64) was associated with all-cause mortality, loneliness (Mild: OR = 0.83, 95%CI:0.59–1.16; Severe: OR = 1.03, 95%CI:0.71–1.64), and the interaction between loneliness and social isolation were not associated with all-cause mortality. Conclusion Social isolation, but not loneliness or their interaction, was associated with all-cause mortality in Mexican adults older than 50 years. This finding may help direct possible future interventions that help improve mental health in older adults from a highly collectivistic country.
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Best Leeds Bradford Airport deals for last minute holidaysIf you're wanting a last-minute February break away then these are the best deals flying from Leeds Bradford Airport
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