An investigational allogeneic stem cell–derived pancreatic islet cell replacement therapy continues to show promise as a treatment for type 1 diabetes, according to the latest data, from six patients thus far.
, was used to protect the cells from the recipient's immune system. After the infusion, all six participants had C-peptide production, reduction in A1c despite reduced insulin use, and no severe hypoglycemia episodes from day 90 onwards.
, so should anything go bad you remove immunosuppression and the cells would be destroyed by the immune system. So it's a perfect trial in a way." Nostro, who gave an introductory presentation at the beginning of the symposium where the VX-880 data were presented, explained that in a current trial of genetically modified cells,"they're placing the product inside a device so that the cells would be retrievable. It might not be perfect but at least it's going to tell us whether the genetically modified product is safe, which I think is what we need to use.
She told Medscape:"[VX-880] is the beginning. This is the first product that's going to be in the clinic, but I can imagine how five, 10 years from now we will have different and more enhanced solutions for type 1 diabetes and who knows, maybe even for type 2."
France Dernières Nouvelles, France Actualités
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