25% of COVID-19 patients have lasting reduction in lung function Coronavirus Disease COVID LungCapacity Lungs LungFunction Respiratory SSRN TheLancet GGDAmsterdam UvA_Amsterdam
By Dr. Chinta SidharthanFeb 28 2023Reviewed by Danielle Ellis, B.Sc. *Important notice: Preprints with The Lancet / SSRN publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Fatigue, myalgia, and dyspnea are commonly reported symptoms from long COVID or PASC patients. Recent studies indicate that lower diffusing capacity for carbon monoxide and an associated reduction in the alveolar volume is the prevalent lung abnormality in PASC patients. These findings are primarily based on hospitalized patients, and persistent impairments with pulmonary functions have been linked to prolonged hospitalization, ventilator use, and intensive care unit admissions.
Information on the occurrence and duration of PASC symptoms was collected using a questionnaire, and medical history and sociodemographic data were obtained from interviews and medical records. During the acute phase of SARS-CoV-2 infections, physical measurements such as respiratory rate, oxygen saturation, and heart rate were collected during enrolment, as well as one week and one month after enrolment.
Results The findings reported that at 12 months of follow-up, one-fourth of the participants continued to have impaired pulmonary function, with mild, moderate, and severe SARS-CoV-2 infections accounting for 11%, 22%, and 48% of these cases, respectively. While the DLCO values improved over time, three or more comorbidities and severe or critical initial SARS-CoV-2 infections were associated with decreased pulmonary function improvement rates.
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